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PDE/ADE reports

Azierta is an European scientific reference company in developing PDE/ADE reports.

Now you can request your PDE reports online (Permitted Daily Exposure) for any custom API.


What PDE is in toxicology?

In accordance with the 'Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities' (EMA/CHMP/ CVMP/ SWP/169430/2012) the determination of health based exposure limits for a residual active substance is based on the calculation of the Permitted Daily Exposure (PDE)/ADE.


What ours PDE/ADE reports include?

  • Hazard identification by reviewing all relevant data.
  • Identification of 'critical effects'.
  • Determination of the no-observed-adverse-effect level (NOAEL) of the findings that are considered to be critical effects.
  • Use of several adjustment factors to account for various uncertainties.

Azierta, toxicological experts, is formed by a multidisciplinary team that count with certified members by AETOX, EUROTOX and ERT.

PDE ADE reports Eurotox

Request online your PDE/ADE report

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  • abiraterone acetate
  • aceclofenac
  • aceclofenac
  • acetic acid
  • acetic acid
  • acetic acid
  • acetylcysteine
  • acetylcysteine
  • acetylsalicilic acid
  • aclidinium
  • acyclovir
  • acyclovir
  • acyclovir
  • adrenaline tartrate
  • aesculus hippocastanun ext
  • aesculus hippocastanun ext
  • afatinib
  • agnus castus (vitex agnus castus)
  • agomelatine
  • albumin tannate
  • alendronate
  • alendronate
  • alendronate sodium
  • alfentanil
  • alfuzosine hcl
  • alimemazine hemitartrate
  • aloe ferox_capae aloe
  • alpha-lactalbumine
  • alprazolam
  • alprostadil
  • aluminium
  • aluminum formate
  • aluminum formate
  • aluminum magnesium silicate
  • alverine citrate
  • amantadine hcl
  • amantadine hcl
  • ambroxol hcl
  • ambroxol hcl
  • aminophylline
  • amitriptyline
  • amlodipine
  • amlodipine besylate
  • amlodipine mesylate
  • amlodipine mesylate monohydrate
  • ammi visnaga
  • ammi visnaga
  • ammonia
  • amorolfine hcl
  • amoxicillin sodium
  • amoxicillin trihydrate
  • amoxicillin
  • ampicillin
  • ampicillin
  • amyleine hydrochloride
  • amyleine hydrochloride
  • antazoline sulphate
  • apixaban
  • apomorphine
  • apomorphine
  • aripipazole
  • aripipazole
  • articaine hcl
  • artichoke extract (cynara scolymus)
  • ascorbic acid
  • ascorbic acid
  • atenolol
  • atorvastatin
  • atropine sulfate
  • aurantii amari (bitter orange)
  • azaperone
  • amiloride hci
  • aluminium hydroxyde
  • alendronate
  • bactipal 5/14
  • balsalazide
  • balsalazide
  • balsalazide
  • batroxobin
  • beclomethasone dipropionate
  • beclomethasone dipropionate
  • beclomethasone dipropionate
  • bendroflumethiazide
  • benzoic acid
  • benzoic acid
  • benzoic acid
  • benzoxazocine (nefopam hcl)
  • benzoxazocine (nefopam hcl)
  • benzydamine hydrochloride
  • benzyl alcohol
  • betacarotene
  • betahistine
  • betamethasone
  • betamethasone
  • betamethasone
  • betamethasone sodium phosphate
  • betamethasone sodium phosphate
  • betamethasone sodium phosphate
  • bht
  • bht
  • bht
  • bifonazole
  • biotin (vitamin h)
  • biotin (vitamin h)
  • bismuth iodosubgallate
  • bismuth iodosubgallate
  • bitter fennel oil
  • black cohosh dry extract (cimicifuga racemosa, ext.)
  • boldus extract
  • boldus extract
  • brimonidine tartrate
  • brimonidine tartrate
  • brimonidine tartrate
  • bromazepam
  • bromide
  • bronopol
  • budesonide
  • budesonide
  • bupivacaine
  • bupivacaine hcl monohydrate
  • butafosfan
  • butafosfan
  • butenafine hcl
  • butylhydroxyanisole
  • buclizine hydrochloride
  • bictegravir
  • benzalkonium chloride
  • benzalkonium chloride
  • benzalkonium chloride
  • buprenorphine
  • buprephinone hcl
  • ca-dtpa
  • caffeine anhydrous
  • calcitriol
  • calcitriol
  • calcitriol
  • calcium carbonate
  • calcium carbonate
  • calcium chloride
  • calcium chloride
  • calcium chloride
  • calcium dobesilate
  • calcium folinate / levoleurovin calcium
  • calcium gluconate
  • calcium iodate anhydrous
  • calcium levofolinate / leucovorin calcium
  • calcium pantothenate
  • calcium phosphate dibasic
  • calendula officinalis
  • calendula officinalis
  • camphor
  • camphor
  • candesartan
  • candesartan cilexetil
  • carbamazepine
  • carbamazepine
  • carbidopa
  • carbimazole
  • carglumic acid
  • carmellose
  • carvedilol
  • cascara extract
  • caulophyllum
  • cefaclor
  • cefaclor monohydrate
  • cefadroxil monohydrate
  • cefamandole nafate
  • cefathiamidine
  • cefazedone sodium
  • cefazoline
  • cefazoline
  • cefdinir
  • cefepime
  • cefepime
  • cefminox sodium
  • cefodizime sodium
  • cefonicid sodium
  • cefoperazone
  • cefotaxime
  • cefotaxime
  • cefoxitin sodium
  • cefpodoxim proxetil
  • cefquinom sulfate
  • ceftazidime
  • ceftezole sodium
  • ceftibuten hydrate
  • ceftizoxime sodium
  • ceftriaxone
  • ceftriaxone
  • ceftriaxone sodium
  • cefuroxime
  • cefuroxime axetil
  • cefuroxime axetil
  • celecoxib
  • centaurii herba
  • cephaelis ipecacuanhae radix
  • cephalexin
  • cephalexin
  • cephalexin monohydrate
  • cephalexin monohydrate
  • cephradine
  • cetearyloctanoat
  • cetearyloctanoat
  • cetirizine hydrochloride
  • chloral betaine
  • chloral hydrate
  • chlorambucil
  • chlordiazepoxide hcl
  • chlorhexidine gluconate
  • chlorhexidine gluconate
  • chlormadinone acetate
  • chlorobutanol hemihydrate
  • chlorpheniramine maleate
  • chlorthalidone
  • chlortetracycline hcl
  • chlortetracycline hcl
  • chlorzoxazone
  • cholecalciferol (vitamina d3)
  • cholecalciferol (vitamina d3)
  • cholestyramine
  • cholic acid
  • choline salicylate
  • chromic chloride hexahydrate
  • cinacalcet
  • cineraria maritima
  • cineraria maritima
  • cineraria maritima
  • cinnarizine
  • ciprofloxacin
  • ciprofloxacin
  • cisatracurium besylate
  • citalopram
  • citalopram hydrobromide
  • citalopram hydrochloride
  • citric acid
  • citric acid
  • citric acid
  • clarithromycin
  • clevidipine
  • clindamyicin hydrochloride
  • clindamyicin hydrochloride
  • clindamyicin hydrochloride
  • clomethiazol
  • clomethiazol edysilate
  • clopidogrel hydrogen sulphate (clopidogrel bisulfate)
  • clotrimazole
  • clotrimazole
  • clove oil
  • clove oil
  • cloxacillin benzathine
  • cloxacillin sodium
  • clozapine
  • cobalt acetate and carbonate
  • cobicistat
  • cocamidopropyl betaine
  • cocamidopropyl betaine
  • crataegus laevigala/monogyna
  • crataegus laevigala/monogyna
  • crisaborole
  • cromoglycate sodium
  • cyamemazine
  • cyamemazine
  • cyanocobalamin
  • cyanocobalamin
  • cyclamen purpurascens
  • cyclizine lactate
  • cyclobenzaprine hydrochloride
  • cyclohexanone
  • clobazan
  • carbenoxolone
  • dantrolene sodium
  • dectaflur
  • dequalinium chloride
  • dequalinium chloride
  • desoxymethasone
  • desvenlafaxine
  • dexamethasone
  • dexamethasone
  • dexamethasone
  • dexamethasone
  • dexmedetomidine hcl
  • dexpanthenol
  • dexrabeprazole sodium
  • diacetylmorphine
  • diazepam
  • diazepam
  • diazepam
  • diclofenac
  • diclofenac and salts
  • diclofenac and salts
  • diclofenac and salts
  • dicycloverine hcl
  • didecyldimethylammonium chloride
  • didecyldimethylammonium chloride
  • dihydrocodeine
  • dihydroergotamine mesylate
  • dimetindene maleate
  • diphenhydramin hcl
  • diphenhydramin hcl
  • diphenylpyraline hcl
  • dipropyleneglycolmonomethylether
  • disulfiram
  • dithymol
  • dobutamine hydrochloride
  • docetaxel
  • domperidone
  • donepezil hydrochloride
  • dota
  • doxepin
  • doxepin hydrochloride
  • doxofylline
  • doxofylline
  • doxorubicin
  • doxycycline hyclate
  • doxycycline hyclate
  • d-penicillamine
  • dry extract of chaste tree fruit
  • dutasteride
  • dydrogesterone
  • dydrogesterone
  • dexamphetamine sulfate
  • echinacea
  • echinacea
  • echinacea purpurea/angustifolia
  • echinacea purpurea/angustifolia
  • econazole nitrate
  • econazole nitrate
  • elderberry dry extract
  • elvitegravir
  • enalapril
  • entacapone
  • ephedrine hydrochloride
  • epinephrine hydrochloride
  • epirubicin hydrochloride
  • epoprostenol
  • eptifibatide
  • ergometrine maleate
  • ergotamine tartrate
  • erlotinib
  • erlotinib hcl
  • ertapenem sodium
  • erythromycin
  • eslicarbazepine
  • eslicarbazepine acetate
  • esomeprazol
  • esomeprazol
  • esomeprazole magnesium
  • estradiol
  • estradiol hemihydrate
  • estradiol valerate
  • estriol
  • estrone
  • ethinylestradiol
  • ethyl-2-bromoisovalerate
  • ethylmorphine hcl
  • etilefrine hydrochloride
  • etoricoxib
  • etoricoxib
  • eudemine (diazoxide)
  • extract of arnica montana
  • extract of cimicifuga racemosa
  • extract of olea europaea
  • extract of uva ursi
  • ezetimibe
  • estradiol
  • farfarae folia
  • febuxostat
  • felypressine
  • felypressine
  • fenbendazole
  • fentanyl citrate
  • fentanyl citrate
  • fenticonazole nitrate
  • fenticonazole nitrate
  • ferrous fumarate
  • ferrous sulfate monohydrate
  • finasteride
  • fingolimod hydrochloride
  • finrozole
  • fluconazol
  • fluconazol
  • flucytosine
  • flumazenil
  • flunarizine dihydrochloride
  • fluocinolone acetonide
  • fluoxetine
  • fluoxetine hydrochloride
  • flurazepam
  • fluvastatin
  • folic acid
  • fraxini cortex (esculin)
  • fumaria
  • furosemide
  • furosemide
  • fenobarbitate (phenobarbital)
  • fenobarbitate (phenobarbital)
  • fexofenadine hci
  • fentanyl citrate
  • fluorouracil
  • fluticasone furoate
  • gabapentin
  • ganirelix acetate
  • garlic oil ( allium sativum l.)
  • gefitinib
  • gemcitabine hydrochloride
  • gentamycin
  • gentamycin
  • gentamycin sulphate
  • ginkgo biloba
  • ginseng extract
  • gliclazide
  • glimepiride
  • glucosamine
  • glucosamine hydrochloride
  • glucosamine sulphate
  • glucose anhydrous
  • glucose monohydrate
  • glucose monohydrate
  • glutaraldehyde
  • glycerol
  • glycerol
  • glycopyrrolate
  • glycopyrronium bromide
  • glycopyrronium bromide
  • glycosylated anthraquinones rhubarb
  • granisetron hydrochloride
  • grape seed extract
  • guaifenesin
  • guaifenesin
  • guar gum
  • glyoxal
  • glyoxal
  • glibencamide
  • glycerol
  • harpagophytum
  • hedera helix
  • heparin sodium
  • heparin sodium
  • heparin sodium
  • hyoscine butylbromide
  • hyoscine butylbromide
  • histamine dihydrochlroride
  • humulus lupulus
  • hydrochlorotiazide
  • hydrocortisone hemisuccinate
  • hydromorphon hcl
  • hydroxyzine hydrochloride
  • hyoscyamus
  • hypromellose
  • hydroxyzine pamoate
  • ibuprofen
  • ibuprofen lysine
  • idebenone
  • ignatia amara
  • imatinib
  • imatinib mesylate
  • indomethacin
  • irinotecan hcl trihydrate
  • iron
  • iron dextram
  • iron oxide
  • isoconazole
  • isoconazole nitrate
  • isoleucine
  • isoniazid
  • isosorbide dinitrate
  • isosorbide dinitrate
  • isosorbide mononitrate
  • itraconazole
  • ivermectin
  • ivermectin
  • ivermectin
  • ibandronate
  • indomethacin
  • isopropanol_isopropylalcohol
  • There are no products available in this category

  • k30 (povidone)
  • kalmegh
  • kalopanaxsoponin b
  • kaolin
  • kava-kava (piper methisticum )
  • ketamin hcl
  • ketoprofen
  • ketoprofen
  • ketoprofen
  • ketorolac trometamol
  • ketorolac trometamol
  • ketorolac trometamol
  • ketamine hydrochloride
  • ketotifen hydrogen fumarate
  • l-5-hydroxytryptophan
  • labetalol hcl
  • labetalol hcl
  • lacosamide
  • lactic acid
  • lactic acid
  • lactitol monohydrate
  • lactulose
  • l-a-glycerylphosphorilcholine
  • lenvatinib mesylate
  • lercanidipine
  • leucine
  • leuprolide acetate
  • levetiracetam
  • levistici radix
  • levodopa
  • levofloxacin
  • levofloxacin hemihydrate
  • levofloxacin hemihydrate
  • levomepromazine
  • levomepromazine
  • levomethadone
  • levomethadone hcl
  • levonorgestrel
  • levosimendan
  • levosulpiride
  • levothyroxine na
  • lichen islandicus (cetraria islandica)
  • lidocaine
  • lidocaine
  • lidocaine
  • lidocaine hydrochloride
  • lidocaine hydrochloride
  • lincomycin hydrochloride
  • liothyronine sodium
  • liquid paraffin
  • liquid paraffin
  • liquiritae radix
  • loperamide
  • loperamide hydrochloride
  • lorazepam
  • lorcaserine hcl
  • losartan
  • losartan potassium
  • laurylamine dipropylenediamine
  • macitentan
  • magnesium carbonate
  • magnesium chloride
  • magnesium chloride
  • magnesium citrate
  • magnesium hydroxide
  • magnesium hydroxide
  • magnesium oxide
  • magnesium sulphate
  • magnesium trisilicate
  • magnesium trisilicate
  • magnolia
  • malt
  • maxacalcitol
  • mebeverine hcl
  • meclozine hydrocloride
  • mecysteine hydrochloride
  • medroxyprogesterone acetate
  • medroxyprogesterone acetate
  • meglumine antimoniate
  • melarsoprol
  • melisa officinalis
  • meloxicam
  • meloxicam
  • menthol OTHER
  • menthol
  • menthol
  • menyanthes trifoliata l.
  • mesalazin (mesalamine)
  • mesalazine
  • metamizol sodium monohydrate
  • metamizole
  • metamizole
  • metaxalone
  • metformin
  • metformin hcl
  • methionine
  • methocarbamol
  • methotrexate
  • methyl paraben sodium
  • methyl paraben sodium
  • methyl paraben sodium
  • methyldopa
  • methyldopate
  • methylergonovine
  • methylergonovine
  • methylsulfonylmethane
  • metoclopramide
  • metoclopramide
  • metoprolol succinate
  • metoprolol tartrate
  • metronidazole
  • metronidazole
  • metronidazole hydrochloride
  • metronidazole hydrochloride
  • mifepristone
  • minoxidil
  • mirtazapine
  • misoprostol
  • mitoxantrone
  • mitoxantrone hcl
  • mivacurium chloride
  • monoammonium glygcyrrhizinate
  • morphine sulfate
  • moxidectin
  • moxifloxacin
  • moxisylite hcl
  • mupirocine
  • mupirocine calcium
  • mycophenolate mofetil
  • mycophenolate mofetil
  • meclizine hci (monohydrate)
  • mepivacaine
  • magnesium glycerophosphate
  • methyldopate
  • megestrol acetate
  • metamizole
  • mupirocine calcium
  • naloxone hydrochloride
  • naphazoline nitrate and hydrochloride
  • naproxen
  • naproxen
  • nefopam hydrochloride
  • nefopam hydrochloride
  • neomycine sulfate
  • neostigmine methylsulfate
  • nicotinamide
  • nicotinamide
  • nicotine
  • nifedipine
  • nifedipine
  • nitric acid
  • nitric acid
  • noradrenaline bitartrate
  • norfloxacin
  • nystatin
  • nitric acid
  • nystatine
  • naphazoline nitrate
  • octenidine dihydrochloride
  • octenidine dihydrochloride
  • olaflur
  • olaflur
  • olanzapine
  • olaparib
  • oleandomycin phosphate
  • olmesartan medoxomil
  • olodaterol
  • ondansetron
  • ondansetron
  • opipramol
  • oxalic acid dihydrate
  • oxycodone hydrochloride
  • oxalic acid dihydrate
  • potassium iodine
  • paclitaxel
  • paliperidone
  • paliperidone
  • pancreatin
  • pantoprazole
  • pantoprazole sodium
  • pantoprazole sodium
  • papaverine hydrochloride
  • paracetamol
  • paracetamol
  • paraffin
  • paraffin
  • paricalcitol
  • paricalcitol
  • paroxetine
  • penethamate hydriodide
  • penicillin g benzathine
  • penicillin g procaine
  • penicillin g sodium
  • pentosan polysulfate sodium
  • pepsin
  • perform classic concentrate ga
  • perindopril tertbutylamine
  • pethidine hydrochloride
  • pethidine hydrochloride
  • phenelzine sulfate
  • phenol
  • phenol
  • phenol
  • phenoxyetanol
  • phenoxyetanol
  • phenoxymethylpenicillin calcium
  • phenylalanine
  • phenylephrine hcl
  • phenylephrine hcl
  • phenytoin sodium
  • phloroglucinol
  • phmb
  • phmb
  • phmb
  • phmb
  • phosphoric acid
  • phosphoric acid
  • phthalylsulfathiazole
  • pilocarpine hcl
  • pilocarpine hcl
  • pinus pinaster (maritime pinus)
  • piperaquine
  • pirfenidone
  • pitavastatine
  • pizotifen
  • pizotifen
  • pizotifen
  • pizotifen hydrogen maleate
  • plantago ovata
  • polidocanol
  • polidocanol
  • polidocanol
  • polysorbate 80
  • polystyrene sulfonate salts
  • potassium nitrate
  • potassium bromide
  • potassium chloride
  • potassium chloride
  • potassium dichromate
  • potassium gluconate
  • potassium iodide
  • pramiprexole dihydrochloride
  • prasugrel
  • prednicarbate
  • prednisolone
  • prednisolone
  • prednisolone
  • prednisolone acetate
  • pregabalin
  • prilocaine
  • prilocaine
  • primula radix
  • prochlorperazine maleate
  • progesterone
  • progesterone
  • propafenone hcl
  • propafenone hcl
  • propafenone hcl
  • propargyl alcohol
  • propranolol hydrochloride
  • propyl alcohol
  • propyl alcohol
  • propylparaben sodium
  • propylparaben sodium
  • propylparaben sodium
  • propylthiouracil
  • protamin sulfate
  • prx201848
  • pseudoephedrine sulfate
  • pyridoxine
  • pyridoxine
  • pyridoxine
  • pyridoxine hcl
  • pyrimethamine
  • propylparaben sodium
  • propylparaben sodium
  • propylparaben sodium
  • palbociclib
  • potassium nitrate
  • pvp-iodine
  • quartasept® plus and perform® sterile concentrate q2
  • quetiapine fumarate
  • quetiapine
  • ramipril
  • ramosetron hcl
  • ranitidine hydrochloride
  • ranitidine hydrochloride
  • regorafenib
  • remifentanil hydrochloride
  • rhammus pursiana
  • rhatany (krameria trianda)
  • riboflavin (vit b2)
  • riboflavin (vit b2)
  • riboflavin sodium fosfate
  • riboflavin sodium fosfate
  • rifampicin
  • rivaroxaban
  • rocuronium bromide
  • roflumilast
  • ronidazole
  • rosemary oil
  • rosmarini
  • rosuvastatin
  • rosuvastatin calcium
  • roxithromycin
  • rupatadine fumarate
  • rupatadine
  • risedronate sodium hemapentahydrate
  • riluzole
  • salicylic acid
  • salicylic acid
  • sarecycline
  • sevelamer carbonate
  • sibutramine hydrochloride
  • sildenafil
  • silymarin
  • simethicone
  • simethicone
  • simvastatine
  • sodium acetate
  • sodium alginate
  • sodium ascorbate
  • sodium ascorbate
  • sodium bicarbonate
  • sodium bicarbonate
  • sodium carbonate anhydrous
  • sodium chloride
  • sodium chloride
  • sodium chloride
  • sodium fluoride
  • sodium lactate
  • sodium lauryl sulfoacetate
  • sodium phenylbutyrate // 4-phenyl butyric acid sodium salt
  • sodium phenylbutyrate // 4-phenyl butyric acid sodium salt
  • sodium phosphate tribasic dodecahydrate
  • sodium picosulfate
  • sodium selenite
  • sodium selenite
  • sodium tetradecyl sulfate
  • solifenacine
  • solifenacine succinate
  • sorbic acid
  • soya bean oil
  • sparfloxacin
  • succinylcholine
  • sulbactam sodium
  • sulfaguanidine
  • sulfamethoxazole
  • sulfapyrydine
  • sultamicilline bas and tysolate
  • sumatriptan succinate
  • suxamethonium chloride
  • sodium citrate
  • sodium citrate
  • spiramycin
  • spiramycin
  • sulfadimidine sodique
  • sulfadimidine sodique
  • sodium fluoride
  • tafamidis meglumine
  • tapentadol hydrochloride
  • temazepam
  • terazosin hydrochloride
  • terbinafine
  • terconazole
  • terlipressin acetate
  • testosterone
  • tetrabenazine
  • tetracycline hydrochloride
  • tetracycline hydrochloride
  • tetrahydrozolin
  • theophiline anhydrous
  • thermosept kraftreinger a (potassium hydroxide)
  • thiamin
  • thiamin
  • thiamin hydrochloride
  • thiocolchicoside
  • thymus vulgaris
  • ticarcillin disodium
  • ticlopidine
  • ticlopidine hydrochloride
  • tigecyline
  • tinidazole
  • tiotropium bromide
  • titanium dioxide
  • titanium dioxide
  • titanium dioxide
  • tolcapone
  • tolnaftate
  • tramadol
  • tramadol
  • trandolapril
  • tranexamic acid
  • tranexamic acid
  • tranexamic acid
  • tranexamic acid
  • tranylcypromine
  • tranylcypromine sulfate
  • traxaci herba cum radix
  • trazodone
  • trazodone hydrochloride
  • tretinoin
  • tretinoin
  • triamcinolone acetonide
  • triamcinolone acetonide
  • triamterene
  • tricholine citrate
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  • tropatepine hydrochloride
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  • There are no products available in this category

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  • There are no products available in this category

  • zidovudine
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  • zn-dtpa
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  • 1h-benzotriazole
  • 1h-benzotriazole
  • 2,4,6-trichlorophenol
  • 2,4-dichlorophenol
  • 2,6-dichlorophenol
  • 2-biphenylol
  • 2-biphenylol
  • 4-chlorophenol
  • 2-methyl-2-propanol
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